This article provides information about the political, social, and cultural changes that took place in the Kashkadarya Oasis during the historical millennia, which led to the rise of science and culture in the region, the growth of the population's consciousness, and the development of the way of life. At the same time, shrines located on the territory of the oasis and associated with the names of scientists, saints, pirs, sayyids, khojas, and historical figures became an integral part of the way of life of the local population. A visit to these places by pilgrims allows not only to express respect to the blessed ones but also to become more deeply acquainted with the science of scientists and the achievements of the Fuzalo who significantly contributed to the development of Islamic culture. The article will provide valuable information about the lives and legacies of these outstanding individuals.